Interferon alfa2b for intramuscular, subcutaneous, intralesional, or intravenous injection intron a is a purified sterile recombinant interferon product. Interferons help your bodys immune system respond to bacteria, viruses, cancer, or other invading substances interferon alfa 2b is used to treat hairy cell leukemia, malignant melanoma, follicular lymphoma, kaposis sarcoma caused by aids, and certain types of genital warts. Ocular surface squamous neoplasia treatment eyes wide bay. May 30, 2018 interferon alfa 2b is made from human proteins. Interferon alfa2b should be used cautiously in patients with debilitating conditions such as those with a history of cardiac disease e. Hematologic remission and cytogenetic improvement induced by recombinant human interferon alpha a in. Interferon alfa2b injection and ribavirin combination may cause a dry mouth. Case report pegylated interferonassociated severe retinopathy in a patient with chronic hepatitis hee young kang1. Ibm micromedex along with its needed effects, a medicine may cause some unwanted effects. In some cases, health care professionals may use the trade names intron a, roferona or other names such as ifnalpha and alpha interferon when referring to the generic drug name interferon alfa. Intravitreal interferon alpha2b for the treatment of neovascular agerelated macular degeneration. To report the efficacy and safety of interferon alpha 2b in the treatment of pseudophakic cystoid macular edema resistant to conventional therapy.
Baseline central macular thickness cmt and bestcorrected visual acuity bcva were compared with those at followup. Once youve done two rounds, return to your sprints. Interferon alfa2b is also used to treat chronic hepatitis b or c in. Symptoms of a serious allergic reaction to alphainterferon may include itching, swelling of your face, tongue, throat, trouble breathing, feeling dizzy or faint, and chest pain.
Interferon alfa 2b may make you tired or unable to concentrate. Interferon alfa 2b injection is used alone or in combination with ribavirin copegus, rebetol, ribasphere to treat chronic longterm hepatitis c infection swelling of the liver caused by a virus in people who show signs of liver damage. Comparison of the effects of subconjunctival injections of. Although not all of these side effects may occur, if they do occur they may need medical attention. Interferon beta1b injection is used to reduce episodes of symptoms in patients with relapsingremitting course of disease where symptoms flare up from time to time of multiple sclerosis ms, a disease in which the nerves do not function properly and patients may experience weakness, numbness, loss of muscle coordination and problems with vision, speech, and bladder control. Interferon alpha2a for subfoveal neovascularization in age. In a pilot study, karp et al 2010 examined the effectiveness of pegylated interferon alpha 2b pegifnalpha2b for treatment of ocular surface squamous neoplasia ossn. Efficacy and tolerability of interferon alpha treatment in patients. This medicine has similar actions to natural interferons and is used to treat aidsrelated kaposis sarcoma, certain types of hepatitis or certain cancers. Our findings of increased choroidal circulation after treatment of the eye with interferon alpha 2b indicate a possible effect of this cytokine on blood circulation.
They are approved for medical use to regulate immune responses in many disease states. Pegylated interferons have a covalently attached 40 kda branched chain polyethylene glycol moiety, which improves drug absorption and prolongs the halflife from 4 to 2260 hours, allowing for less frequent injections and improved patient compliance. To report the effect of subtenon injections of natural leukocyte interferon. Is screening for interferon retinopathy in hepatitis c. Interferon alfa2b injection advanced patient information. Before you use interferon alfa2b for the first time, you or the person who will be giving the injections should read the manufacturers information for the patient that comes with it. Interferon injections may resolve ocular surface squamous. Interferon alpha 2b in the treatment of uveitic cystoid. A interferon alfa2b for intramuscular, subcutaneous, intralesional, or intravenous injection is a purified sterile recombinant interferon product.
Vitrectomy and grid macular laser were used with some success before the introduction of antivegf injections and intravitreal steroid implants. Interferon, a natural multifunctional protein, has been an important part of medical therapy in various ophthalmic indications. The current study is a prospective randomized clinical trial to determine the effect of interferon alpha2a on eyes with subfoveal subretinal neovascularization secondary to agerelated macular. Twentyfour wistar albino rats were used in this study. In the treatment of hepatitis c, the national institute for clinical excellence advocates use of a combination of interferon alfa and ribavirin for selected patients. Choroidal changes after intravitreal injection of interferon alpha2b. Patients should be monitored closely with periodic clinical and laboratory evaluations.
Interferon alfa2a, recombinant roferona is a sterile protein product for use by injection. Interferon alfa 2b injection and ribavirin combination may cause a dry mouth. Check with your physician if you have any of the following. The following conditions are contraindicated with this drug. Powder for solution alpha interferons, including interferon alfa2b, cause or aggravate fatal or lifethreatening neuropsychiatric, autoimmune, ischemic, and infectious disorders. Shah is an ophthalmologist in ventura, california and is affiliated with multiple hospitals in the area. The information provided in therapeutic indications of bioferon interferon alfa2b is based on data of another medicine with exactly the same composition as the bioferon interferon alfa2b of the medicine interferon alfa2b. Retrospective cohort of patients with postuveitic refractory me, who received subcutaneous ifn alpha 2a injections for at least 3 months. Pegylated interferon alphaassociated optic neuropathy. Full text update in treatment of uveitic macular edema. Topical interferon alpha 2b in the treatment of refractory. Intron a interferon alfa2b, recombinant for injection. Powder for solution alpha interferons, including interferon alfa 2b, cause or aggravate fatal or lifethreatening neuropsychiatric, autoimmune, ischemic, and infectious disorders.
Interferon associated retinopathy british journal of ophthalmology. Recent progress in the treatment of uveitic macular edema. The drug is administered within 56 days after surgery. There has been recent interest in the use of systemic interferon alfa2a treatment for choroidal neovascular membranes cnv. Interferon versus methotrexate in intermediate uveitis with macular edema. Intralesional interferonalpha2b injections for the treatment of peyronies disease. Clinical experience with interferon alfa2a for exudative age. Since 1993, ocular complications following interferon therapy have been. Jun 04, 2018 intron a interferon alfa 2b is an alpha interferon made from human proteins used to treat hairy cell leukemia, malignant melanoma, follicular lymphoma, kaposis sarcoma caused by aids, certain types of genital warts, and chronic hepatitis b or c. Antibiotics can kill off the useful bacteria in the body, such as those that help digestion. Our findings of increased choroidal circulation after treatment of the eye with interferon alpha2b indicate a possible effect of this cytokine on blood circulation.
Be careful and be sure to specify the information on the section therapeutic indications in the instructions to the drug bioferon interferon alfa2b directly from. Interferons medical clinical policy bulletins aetna. Campossubtenon injection of natural leukocyte interferon. Ocular surface irritation was the only reported adverse effect of the treatment in our patient, this responded to lubricants. An update on the treatment of hemangiomas in children with. Interferons help your bodys immune system respond to bacteria, viruses, cancer, or other invading substances. The aim of this study is to compare the effectiveness of bevacizumab and interferon alpha2a ifn. In this study, we did not observe any clinical or histopathologic evidence for retinal toxicity after intravitreal injection of 200,000 iu0. Common adverse reactions include injection site inflammationreaction, fatigueasthenia, headache, rigors, fevers, nausea, myalgia and anxietyemotional labilityirritability. Interferon versus methotrexate in intermediate uveitis with macular. Roferona is manufactured by recombinant dna technology that employs a genetically engineered escherichia coli bacterium containing dna that codes for the human protein. Since speed kills it is always better to slow down. Intron a recombinant for injection has been classified as an alpha interferon and is a watersoluble protein with a molecular weight of 19,271 daltons produced by recombinant dna techniques.
Ocular complications with highdose interferon alpha in chronic. Medical treatments may be mitomycinc or interferon alpha 2b, which as eye drops, are able to treat the entire ocular surface for abnormal cells. Interferon alpha 2b in the treatment of uveitic cystoid macular edema. Do not drive or do anything else that could be dangerous until you know how interferon alfa 2b affects you. Development or exacerbation of fatal or lifethreatening ischemic disorders has been observed in patients receiving alpha interferons. Interferon alfa2b side effects, dosage, interactions. Some of the dosage forms listed on this page may not apply to the brand name intron a in summary. Corneal neovascularization cnv is a visionthreatening condition arising from various corneal diseases. After that, you can inject interferon alfa2b yourself or have a friend or relative give you the injections.
Indications for interferon alfa2a therapy have since expanded to include hemangiomas that are cosmetically or functionally deforming, of massive size, or life threatening eg, airway compromise or consumptive coagulopathy. Listing a study does not mean it has been evaluated by the u. The fermentation is carried out in a defined nutrient medium containing the antibiotic tetracycline hydrochloride at a concentration of 5 to 10 mgl. For temporary relief of mouth dryness, use sugarless candy or gum, melt bits of ice in your mouth, or use a saliva substitute. Agerelated macular degeneration medical clinical policy. Pegylated interferon alfa2b is a antiviral that is fda approved for the treatment of chronic hepatitis c chc in patients with compensated liver disease.
These mechanisms help in the recognition and targeting of neoplastic cells. Interferon alfa2b is indicated for the treatment of hairy cell leukemia, malignant melanoma, follicular nonhodgkins lymphoma, condylomata acuminata, aidsrelated kaposis sarcoma, chronic hepatitis c, and chronic hepatitis b. Macular structure and visual acuity were stable throughout a thirtysix weeks followup period. Interferon alfa2a is indicated for the treatment of chronic hepatitis c and hairy cell leukemia in patients 18 years of age or older. Algorithms for the automated analysis of agerelated macular degeneration biomarkers on optical coherence tomography. Efficacy and tolerability of interferon alpha treatment in patients with chronic cystoid macular oedema due to noninfectious uveitis. To assess the efficacy of interferon ifn alpha 2a in the treatment of postuveitic refractory macular edema me methods. The efficacy of intravitreal interferon alpha2b for the. Pdf topical interferon alpha 2b in the treatment of refractory. Inclusion or absence of a drug label on the aidsinfo site does not imply endorsement or lack thereof by aidsinfo.
Intron a alone is a treatment for certain types of cancers and hepatitis b virus. Find patient medical information for interferon alfa2b injection on webmd including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Interferon alpha2a for subfoveal n eovascularization in agerelated macular degeneration lon s. Off label use is based on firm scientific method and sound medical evidence, but means that the drug has been approved by the food and drug administration. Intron a is often used in combination with another drug called ribavirin rebetol.
To study the efficacy of intravitreal interferon alpha 2b for endotoxininduced uveitis. Iterferon alpha is a complex glycoprotein with antiproliferative, antiviral, and immunomodulatory activity. Ophthamologists diagnose and treat eye diseases, including vision loss. Interferons caused many longterm side effects partly because of this long treatment time. Interferon alfa2 interferon alfa2 interferon alfa2 audio icon audio icon brand name. Interferons help your bodys immune system respond to bacteria, viruses, cancer, or other invading substances interferon alfa2b is used to treat hairy cell leukemia, malignant melanoma, follicular lymphoma, kaposis sarcoma caused by aids, and certain types of genital warts. Interferons in ophthalmology current status and advancing. Oct 28, 20 to report the effect of subtenon injections of natural leukocyte interferon. Sep 10, 2011 the two eyes that did not respond to interferon alpha2b injections were treated four times daily with topical mitomycin c 0. Interferon alfa2b intron a interferon alpha2b is indicated for the treatment of malignant melanoma as an adjuvant to surgical treatment in patients with melanoma that are free of disease postsurgery but at high risk for systemic recurrence.
This document contains side effect information about interferon alfa2b. Intravitreal interferon alpha2b for the treatment of neovascular age. Alpha interferon in various formulations has been developed as therapy of several forms of cancer and viral infections, but its major use has been as therapy of chronic. Intron a interferon alfa2b uses, side effects, dosage. The efficacy of intravitreal interferon alpha2b for the treatment of experimental endotoxininduced uveitis mehrdad afarid 1, hamid lashkarizadeh 1, mohammad j ashraf 2, mohammad hossein nowroozzadeh 1, sayed m shafiee 3 1 department of ophthalmology, poostchi eye research center, shiraz university of medical sciences, shiraz, iran 2 department of pathology, shiraz university of medical. Several fdaapproved drug labels may be available for peginterferon alfa2b. Based on its antiinflammatory, antiproliferative, and antiangiogenic effects, systemic and subtenon interferon alpha has been employed in the treatment of a wide range of posterior segment problems with an inflammatory component such as. Ischemic and hemorrhagic cerebrovascular events have been observed in patients treated with interferon alfa 2b. It is a recombinant form of the protein interferon alpha 2 that was originally sequenced and produced recombinantly in e. Choroidal changes after intravitreal injection of interferon. Aflibercept zaltrap, eylea vegf metastatic colorectal cancer, wet macular degeneration cytokines interferons interferon alfa2a roferon chronic hepatitis c interferon alfa2b intron a chronic hepatitis b, chronic hepatitis c, carcinoid tumor, melanoma, multiple myeloma, leukemia interferon beta1a rebif, avonex multiple sclerosis. Interferon alpha is the generic name for the trade name drugs intron a, roferona. Aidsinfo provides the following drug label solely as an example of the labels available for peginterferon alfa2b.
Nov 09, 2018 interferon alfa 2b can harm an unborn baby or cause a miscarriage. This retrospective case series of patients with giant ocular surface squamous neoplasia ossn found that primary immunotherapy and immunoreduction with topical or injection interferon alpha2b ifn. Topical interferon alpha 2b in the treatment of refractory pseudophakic cystoid macular edema. Interferon alpha2a is ineffective for patients with choroidal neovascularisation. Recombinant interferon alfa 2b in treating patients with melanoma the safety and scientific validity of this study is the responsibility of the study sponsor and investigators. There is a black box warning for this drug as shown here. Interferon alfa2b injection route precautions mayo clinic.
To determine the efficacy of interferon alpha 2b in the treatment of refractory, uveitic cystoid macular edema cme. Interferon alpha2b appears effective for giant ossn. Here a pilot study is reported in which 10 patients with exudative agerelated macular degeneration armd have been treated with a course of interferon injections. Interferon alfa 2b injection is used to treat a number of conditions. Retrospective analysis of an interventional case series. Interferon alfa 2b is used to treat hairy cell leukemia, malignant melanoma, follicular lymphoma, kaposis sarcoma caused by aids, and certain types of genital warts. Intron a 5ml diluent interferon alfa2b, recombinant. Interferon alfa 2b is an antiviral or antineoplastic drug. Interferon alpha2a treatment for postuveitic refractory.
A view of the current and future role of optical coherence tomography in the management of agerelated macular degeneration. To perform a prospective pilot study to evaluate interferon alfa 2a ifn alfa 2a for the treatment of refractory cystoid macular edema cme in endogenous uveitis. Natural interferons are produced in the body to help the immune system fight viral infections and certain cancer growths. This study shows that a interferon alpha 2b, in the doses used, is welltolerated by the human eye, and b interferon alpha 2b may reduce the risk of failure of glaucoma filtration surgery with. Pharmacological therapy for macular degeneration study group. Clinical experience with interferon alfa2a for exudative. Do not use interferon alfa 2b with ribavirin rebetol if you are pregnant. Subtenon injection of natural leukocyte interferon.
Ophthalmologic disorders decrease or loss of vision, retinopathy including macular edema, retinal artery or vein thrombosis, retinal hemorrhages and cotton wool spots, optic neuritis, and papilledema may be induced or aggravated by treatment with pegintron alpha 2b or other alpha interferons. Interferons are classified as alpha, beta and gamma interferons based on molecular structure and grouped into types 1 and 2 depending on their cellular effects. A 66yearold man affected by dme, with glycated hemoglobin hba1c at 6. Find patient medical information for interferon alfa 2b injection on webmd including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Sep 25, 20 interferon, a natural multifunctional protein, has been an important part of medical therapy in various ophthalmic indications. This case report displays the potential efficacy and safety of interferon alpha 2b in the treatment of refractory cystoid macular edema after cataract surgery. However, if your mouth continues to feel dry for more than 2 weeks, check with your medical doctor or dentist.
The specific activity of interferon alfa2b, recombinant is approximately 2. Reviews hypersensitivity reactions to biological drugs. Trends in topical chemotherapy american academy of. Interferon alfa2b injection route side effects mayo clinic. Interferon alpha2b is also used for intralesional injections. Ribavirin combined with interferon alfa 2b, interferon alfacon1 infergen, pegylated interferon alfa 2b, or pegylated interferon alpha 2a, all are approved for the treatment of chronic hepatitis c. Pegasys, peginterferon alfa2a, is a covalent conjugate of recombinant alfa2a interferon approximate molecular weight mw 20,000 daltons with a single branched bismonomethoxy polyethylene glycol peg chain approximate mw 40,000 daltons. This is a novel finding that needs further investigation to elucidate mechanisms and.
Ifn, recombinant interferon alfa2a, recombinant interferon alfa 2b, recombinant interferon alpha 2a, recombinant interferon alpha 2b drug class. Recombinant interferon alfa2b in treating patients with melanoma. The efficacy of intravitreal interferon alpha2b for the treatment of. Pdf purpose to report the efficacy and safety of interferon alpha 2b in the treatment of pseudophakic cystoid macular edema resistant to conventional. Interferon alfa2b is an immunological agent that is fda approved for the treatment of patients 18 years of age or older with hairy cell leukemia and indicated as adjuvant to surgical treatment in patients 18 years of age or older with malignant melanoma who are free of disease but at high risk for systemic recurrence, within 56 days of surgery,aidsrelated kaposis sarcoma and. Aug 27, 2011 well the interferon injection is given by subcutaneous mode, but the problem was that we were not getting the marks by which we can give see the markings and give the injection. Jun 05, 2018 interferon treatment for hepatitis c would typically last 2448 weeks 612 months. Product information intron a interferon alfa2b, for. Update on pharmacotherapy for ocular surface squamous.
Interferons in ophthalmology current status and advancing trends. Full text macular edema associated with noninfectious. Retinopathy is a well recognised side effect of interferon therapy and is characterised by retinal haemorrhages, cotton wool spots, and macular oedema. Jun 04, 2018 intron a intronaye interferon alfa2b, recombinant if you are taking intron a with rebetol, also read the medication guide for rebetol ribavirin capsules and oral solution. For example, in january 2001, the food and drug administration fda approved the use of pegylated interferon alpha in the usa.
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